Urea rebound and delivered Kt/V determination with a continuous urea sensor

Urea rebound and delivered Kt/V determination with a continuous urea sensor.

BACKGROUND The recent introduction of urea sensors for dialysis monitoring has made possible new approaches to urea kinetic modelling. In this study we show how the equilibrated postdialysis urea concentration (Ceq) and Kt/V corrected for double-pool urea kinetics (Kt/Vdp) can be accurately determined using an on-line sensor providing a continuous measure of blood water urea. A modification of ...

The Determination of Blood Urea

Most of the methods for the determination of urea in blood involve the use of the enzyme urease to hydrolyze the urea, since this reaction is specific. However, instead of crystalline urease (l), crude jack bean meal extracts are used. These extracts have been found to contain other enzymes besides urease, termed “ammonia-producing” enzymes, and their substrates, which may produce large quantit...

The Determination of Blood Urea

Most of the methods for the determination of urea in blood involve the use of the enzyme urease to hydrolyze the urea, since this reaction is specific. However, instead of crystalline urease (l), crude jack bean meal extracts are used. These extracts have been found to contain other enzymes besides urease, termed “ammonia-producing” enzymes, and their substrates, which may produce large quantit...

Direct Determination of Cyanate in a Urea Solution and a Urea-Containing Protein Buffer

Development of an optical monitoring technology for urea rebound assessment

The aim of the study was to explore the possibility of utilizing UV-absorbance measurements of spent dialysate to assess urea rebound. Ten patients on chronic three-times-a-week hemodialysis were included in the study. On-line UV-absorbance of spent dialysate was monitored. Urea rebound was calculated based on urea concentration in blood (Rb) and UV-absorbance in spent dialysate (Ra). Rb and Ra...